منابع مشابه
BAI1: from cancer to neurological disease
Brain-specific Angiogenesis Inhibitor 1 (BAI1) is a member of the adhesion G protein-coupled receptor (GPCR) sub-family and is mainly expressed in the brain. Structurally, BAI1 has a large N-terminus containing five thrombospondin type 1 repeats (TSR), a putative hormonebinding domain and a GPCR-Autoproteolysis Inducing (GAIN) domain encompassing a GPCR-proteolytic site [1]. The C-terminus of B...
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متن کاملThe role of glia in neurological disease
Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
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Computational models have contributed to current understanding of normal brain function, and can offer new insights into the pathophysiology of neurological disease. We define some of the outstanding clinical questions in stroke, CNS injury, Alzheimer's disease, Parkinson's disease, and epilepsy from a neurologist's perspective, and discuss the potential impact of computational neurology on com...
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M odern microarray-based functional genomics holds great promise for revealing novel molecular and cellular mechanisms of disease. First introduced commercially in 1996, microarrays have been used widely to monitor the expression of thousands of genes in biological samples, as described in the following paragraphs. Other microarray-based genomic applications are also in development, including c...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.8193